Bibliografía

Durante mas de 35 años Lyprinol PCS0 -524 ® Pharmalink International Limites ha empleado los servicios de investigadores individuales e instituciones internacionales punteras con la finalidad de identificar y estudiar los componentes activos presentes en el mejillón Perna Canaliculus . Hoy los frutos de ese proyecto a largo plazo se ven realizados en la extensa bibliografía de Lyprinol PCS0 -524 ®.

BIBLIOGRAFIA

References

A list of clinical studies & references completed on our product

PSCO-524 relieves pain and swelling of arthritis

         Gibson, S. L. M., & Gibson, R. G. (1998). The treatment of arthritis with a lipid extract of Perna canaliculus; a randomised trial. Complimentary Therapies in Medicine, 6, pp. 122-126.

         Halpern, G. M. (2000). Anti-inflammatory effects of a stabilized lipid extract of Perna canaliculus. Allergie and Immunology, 32. pp. 272–278.

         Whitehouse, M. W., Macrides, T. A., Kalafatis, N. (1997). Anti-inflammatory activity of a lipid fraction from the N. Z. green-lipped mussel. Inflammopharmacology, 5, pp. 237–246.

         Whitehouse, M. W., Roberts, M. S., & Brooks, P. M. (1999). Over-the-counter (OTC) oral remedies for arthritis and rheumatism: how effective are they? Inflammopharmacology, 7, pp. 89–105.

         Zawakzki, M., Janosch, C., Szechinski, J. (2013). Perna canaliculus lipid complex PCSO-524® demonstrated pain relief for osteoarthritis patients benchmarked against fish oil, a randomized trial, without placebo control. Marine Drugs, 11, pp. 1920-1935. doi: 10.3390/md11061920

PSCO-524 does not cause bleeding

         Hooper, S. (1998). The Effect of Marine Oils on Markers of Thrombosis in the Blood of Healthy Females. BASc (Hons) Thesis, Royal Melbourne Institute of Technology, Australia.

PSCO-524 does not cause stomach irritation

         Rainsford, K. D., & Whitehouse, M. W. (1980). Gastroprotective and anti-inflammatory properties of green-lipped mussel (Perna canaliculus) preparation. Arzneimittelforschung, 30(12), pp. 2128-2132.

PSCO-524 a more potent anti-inflammatory than prescription drugs

         Gibson, S. L. M., & Gibson, R. G. (1998). The treatment of arthritis with a lipid extract of Perna canaliculus; a randomised trial. Complimentary Therapies in Medicine, 6, pp. 122-126.

         Halpern, G. M. (2000). Anti-inflammatory effects of a stabilized lipid extract of Perna canaliculus. Allergie and Immunology, 32. pp. 272–278.

         Halpern, G. M. (2005). The Inflammation Revolution. Garden City, NY: Square One Publishers.

         Whitehouse, M. W., Macrides, T. A., Kalafatis, N. (1997). Anti-inflammatory activity of a lipid fraction from the N. Z. green-lipped mussel. Inflammopharmacology, 5, pp. 237–246.

         Whitehouse, M. W., Roberts, M. S., & Brooks, P. M. (1999). Over-the-counter (OTC) oral remedies for arthritis and rheumatism: how effective are they? Inflammopharmacology, 7, pp. 89–105.

PSCO-524 reduces severity of asthma

         Emelyanov, A., Fedoseev, G., Krasnoschekova, O., Abulimity, A., Trendeleva, T., & Barnes, P. J. (2002). Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomised clinical trial. European Respiratory Journal, 20, pp. 596-600. doi 10.1183/09031936.02.02632001

         Lello, J., Liang, A., Robinson, E., Leutenegger, D., & Wheat, A. (2012). Treatment of children's asthma with a lipid extract of the New Zealand green lipped mussel (Perna canaliculus) (Lyprinol®) - a double blind, randomised controlled trial in children with moderate to severe chronic obstructive asthma. The Internet Journal of Asthma, Allergy and Immunology, 8(1). doi: 10.5580/2baa

Improve exercise performance

         Baum, K., Telford, R. D., & Cunningham, R. B. (2013). Marine oil dietary supplementation reduces delayed onset muscle soreness after a 30km run. Open Access Journal of Sports Medicine, (4), pp. 109-115. doi.org/10.2147/OAJSM.S41706

         Mickleborough, T. D., Vaughn, C. L., Shei R. J., Davis, E. M., & Wilhite, D. P. (2013). Marine lipid fraction PCSO-524 (Lyprinol®/Omega XL®) of the New Zealand green-lipped mussel attenuates hyperpnea-induced bronchoconstriction in asthma. Respiratory Medicine. doi.org/10.1016/j.med.2013.04.010

         Whitehouse, M. W., Macrides, T. A., & Kalafatis, N. (1997). Anti-inflammatory activity of a lipid fraction (Lyprinol®) from the New Zealand green-lipped mussel. Inflammopharmacology, 5, pp. 237-246.

Fish oil adverse side effects and reactions        

Fish oil causes bleeding

         Bang, H. O., Dyerberg, J., Hjoorne, N. (1976). The composition of food consumed by Greenland Eskimos. Acta Medica Scandinavic, 200, pp. 69-73.

         Dyerberg, J., Bang, H. O. (1979). Homeostatic function and platelet polyunsaturated fatty acids in eskimos. The Lancet, 2, pp. 433-435.

         Gabriel, D. A., Reece, N. S., Li, X., Witte, J. H., Mega, K. M. (1993). Electrophoretic light scattering studies on the interaction of fibrinogen with resting and activated human platelets. Blood Coagulation and Fibrinolysis, 4, pp. 397–403.

         Grottum, K. A. (1969). Platelet surface charge and aggregation. Effects of polyelectrolytes. Thromb Diath Haemorrh 21, pp. 450-462.

         Heemskerk, J. W., Figgie, M. A., Kalafusz, R., Hornstra. G. (1989). Influence of dietary fatty acids on membrane fluidity and activation of rat platelets. Biochimica et Biophysica Acta, 1004, pp. 252-260.

         Kitagawa, S., Endo, J., Kametani, F. (1984). Effects of four types of reagents on ADP-induced aggregation and Ca2+ mobilization of bovine blood platelets. Biochimica et Biophysica Acta, 798, pp. 210-215.

         Kitagawa, S., Nishitama, H., Kametani, F. (1984). Inhibition of ADP-induced aggregation of bovine platelets by saturated fatty acids and its relation with the change of membrane surface charge. Biochimica et Biophysica Acta, 775, pp. 197–202.

         Kitagawa, S., Kotani, K., Kametani, F. (1990). Inhibitory mechanism of cis-polyunsaturated fatty acids on platelet aggregation: the relation with their effects on Ca2+ mobilization, cyclic AMP levels and membrane fluidity. Biochemica et Biophysica Acta, 1054, pp.114-118.

         Sato, T., Nakao, K., Hashizume, T., Fuji, T. (1987). Inhibition of platelet aggregation by unsaturated fatty acids through interference with a thromboxane-mediated process. Biochimica et Biophysica Acta, 931, pp.157-164.

         Sato, T., Hashizume, T., Nakao, K., Akiba, S., Fuji, T. (1989). Platelet desensitization by arachidonic acid is associated with the suppression of endoperoxide/thromboxane A2 binding to the membrane receptor. Biochimica et Biophysica Acta, 992, pp.168-173.